Insulin Resistance in First-Degree Relatives of the Patients with Polycystic Ovarian Syndrome
نویسندگان
چکیده مقاله:
Abstract Objective: Insulin resistance and hyperinsulinemia are common among the women with polycystic ovarian syndrome (PCOS). Familial aggregation of PCOS has implications on the role of heredity in this disease. The aim of this study was to evaluate insulin resistance among the fathers, mothers, and siblings of the women with PCOS referring to the clinics affiliated to Shiraz University of Medical Sciences. Materials and Methods: The present case-control study was conducted on 107 individuals as the case group and 107 individuals as the control group. After recording their height and weight, blood samples were obtained from all the participants in order to assay their serum insulin and blood sugar. Then, the participants were supposed to drink 75 gr glucose solutions and after lapsing 2 hours, blood samples were again taken from all the participants. Finally, the data were analyzed using independent t-test, Fisher's exact test, and chi-square test. P-values less than 0.05 were considered as statically significant. All the statistical analyses were performed through the SPSS statistical software (ver. 11.5). Results: A significant difference was found between the two groups regarding glucose intolerance, obesity, and insulin resistance according to Homeostasis Model Assessment Index (HOMA) and Quantitative Insulin Sensitivity Check Index (QUICKI), and fasting insulin indexes (P<0.05). Moreover, a significant association was observed between android obesity and glucose intolerance (P<0.05), body mass index (≥ 30 Kg/m2), and type II diabetes in the two groups. Conclusion: The first-degree relatives of the women suffering from polycystic ovarian syndrome constitute a risk group and early identification of insulin resistance may prevent the onset and progression of the disease.
منابع مشابه
insulin resistance in first-degree relatives of the patients with polycystic ovarian syndrome
abstract objective: insulin resistance and hyperinsulinemia are common among the women with polycystic ovarian syndrome (pcos). familial aggregation of pcos has implications on the role of heredity in this disease. the aim of this study was to evaluate insulin resistance among the fathers, mothers, and siblings of the women with pcos referring to the clinics affiliated to shiraz university of m...
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Objective: Adiponectin (an insulin sensitizing protein) and zinc have insulin like effect. This study was conducted to assess the effect of zinc supplementation on serum adiponectin and insulin resistance in first degree relatives of diabetic patients. Materials and Methods: This study was a randomized clinical trial performed on 58 first degree relatives of diabetic patients with normal gluco...
متن کاملGlucose intolerance, insulin resistance and cardiovascular risk factors in first degree relatives of women with polycystic ovary syndrome.
BACKGROUND The aim of the present study was to evaluate insulin resistance (IR), glucose tolerance status and cardiovascular risk factors in first degree relatives of patients with polycystic ovary syndrome (PCOS). METHODS A total of 120 family members [Mothers(PCOS) (n = 40), Fathers(PCOS) (n = 38), Sisters(PCOS) (n = 25) and Brothers(PCOS) (n = 17)] of 55 patients with PCOS and 75 unrelated...
متن کاملInsulin resistance and polycystic ovarian syndrome.
Insulin resistance (IR) and polycystic ovarian syndrome (PCOS) appear as linked phenomena, although this is not easy to obviate in common forms of PCOS while it is evident in the rare cases of extreme IR and hyperinsulinism (HI). Experimental data indicate that insulin could interfere with the local insulin-like growth factor systems in ovaries, and presumably in adrenals and in the hypothalami...
متن کاملCorrelation of Serum Lipoprotein Ratios with Insulin Resistance in Infertile Women with Polycystic Ovarian Syndrome: A Case Control Study
Objective Dyslipidemia and insulin resistance (IR), occurring in most infertile women with polycystic ovarian syndrome (PCOS), increase the risk of cardiovascular disease (CVD) and type 2 diabetes. This study aimed to assess the relationships between lipoprotein ratios and IR in PCOS women. MaterialsAndMethods Thirty six infertile women with PCOS selected based on Androgen Excess Society (AES) ...
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عنوان ژورنال
دوره 5 شماره 4
صفحات 163- 170
تاریخ انتشار 2013-12
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